1NPO
BOVINE NEUROPHYSIN II COMPLEX WITH OXYTOCIN
Summary for 1NPO
| Entry DOI | 10.2210/pdb1npo/pdb |
| Descriptor | NEUROPHYSIN II, OXYTOCIN (3 entities in total) |
| Functional Keywords | complex (hormone transport-hormone), hypothalamus, complex (hormone transport-hormone) complex, complex (hormone transport/hormone) |
| Biological source | Bos taurus (cattle) More |
| Cellular location | Secreted: P01180 P01180 |
| Total number of polymer chains | 4 |
| Total formula weight | 21742.78 |
| Authors | Rose, J.P.,Wang, B.-C. (deposition date: 1996-02-01, release date: 1997-02-12, Last modification date: 2024-10-30) |
| Primary citation | Rose, J.P.,Wu, C.K.,Hsiao, C.D.,Breslow, E.,Wang, B.C. Crystal structure of the neurophysin-oxytocin complex. Nat.Struct.Biol., 3:163-169, 1996 Cited by PubMed Abstract: The first crystal structure of the pituitary hormone oxytocin complexed with its carrier protein neurophysin has been determined and refined to 3.0 A resolution. The hormone-binding site is located at the end of a 3(10)-helix and involves residues from both domains of each monomer. Hormone residues Tyr 2, which is buried deep in the binding pocket, and Cys 1 have been confirmed as the key residues involved in neurophysin-hormone recognition. We have compared the bound oxytocin observed in the neurophysin-oxytocin complex, the X-ray structures of unbound oxytocin analogues and the NMR-derived structure for bound oxytocin. We find that while our structure is in agreement with the previous crystallographic findings, it differs from the NMR result with regard to how Tyr 2 of the hormone is recognized by neurophysin. PubMed: 8564543DOI: 10.1038/nsb0296-163 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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