1NPA

crystal structure of HIV-1 protease-hup

1NPA の概要

• エントリーDOI: 10.2210/pdb1npa/pdb
• 分子名称: POL polyprotein, (3S)-TETRAHYDROFURAN-3-YL (1R,2S)-3-[4-((1R)-2-{[(S)-AMINO(HYDROXY)METHYL]OXY}-2,3-DIHYDRO-1H-INDEN-1-YL)-2-BENZYL-3-OXOPYRROLIDIN-2-YL]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• 機能のキーワード: protease, hiv, aspartyl protease, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22237.25

構造登録者

Smith III, A.B.,Hirschmann, R.,Pasternak, A.,Yao, W.,Sprengeler, P.A.,Holloway, M.K.,Kuo, L.C.,Chen, Z.,Darke, P.L.,Schleif, W.A. (登録日: 2003-01-17, 公開日: 2004-01-27, 最終更新日: 2024-02-14)

• 主引用文献: Smith III, A.B.,Hirschmann, R.,Pasternak, A.,Yao, W.,Sprengeler, P.A.,Holloway, M.K.,Kuo, L.C.,Chen, Z.,Darke, P.L.,Schleif, W.A.; An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.; J.MED.CHEM., 40:2440-2444, 1997; PubMed: 9258349; DOI: 10.1021/jm970195u

実験手法

X-RAY DIFFRACTION (2 Å)