1NMK
The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data
Summary for 1NMK
Entry DOI | 10.2210/pdb1nmk/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase A, (13E,15E)-(3S,6S,9R,10R,11S,12S,18S,21S)-10,12-DIHYDROXY-3-(3-HYDROXYBEN-ZYL)-18-((E)-3-HYDROXY-1-METHYLPROPENYL)-6-ISOPROPYL-11-METHYL-9-(3-OXO-BUTYL)-19-OXA-1,4,7,25-TETRAAZA-BICYCLO[19.3.1]PENTACOSA-13,15-DIENE-2,5,8,20-TETRAONE (3 entities in total) |
Functional Keywords | beta sandwich, cyclophilin-ligand complex, cyclosporin, isomerase, rotamase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P62937 |
Total number of polymer chains | 2 |
Total formula weight | 37554.77 |
Authors | Kallen, J.,Sedrani, R.,Wagner, J. (deposition date: 2003-01-10, release date: 2003-04-01, Last modification date: 2023-08-16) |
Primary citation | Sedrani, R.,Kallen, J.,Cabrejas, L.M.M.,Papageorgiou, C.D.,Senia, F.,Rohrbach, S.,Wagner, D.,Thai, B.,Eme, A.-M.J.,France, J.,Oberer, L.,Rihs, G.,Zenke, G.,Wagner, J. Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data J.Am.Chem.Soc., 125:3849-3859, 2003 Cited by PubMed: 12656618DOI: 10.1021/ja021327y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report