1NKR

INHIBITORY RECEPTOR (P58-CL42) FOR HUMAN NATURAL KILLER CELLS

1NKR の概要

• エントリーDOI: 10.2210/pdb1nkr/pdb
• 分子名称: P58-CL42 KIR (2 entities in total)
• 機能のキーワード: inhibitory receptor, natural killer cells, immunological receptors, immunoglobulin fold
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P43626
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22200.90

構造登録者

Fan, Q.R.,Mosyak, L.,Winter, C.C.,Wagtmann, N.,Long, E.O.,Wiley, D.C. (登録日: 1998-06-24, 公開日: 1998-11-11, 最終更新日: 2024-10-30)

主引用文献

Fan, Q.R.,Mosyak, L.,Winter, C.C.,Wagtmann, N.,Long, E.O.,Wiley, D.C.
Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors.
Nature, 389:96-100, 1997

PubMed Abstract: Abnormal cells deficient in class I major histocompatibility complex (MHC) expression are lysed by a class of lymphocytes called natural killer (NK) cells. This lysis provides a defence against pathogens and tumour cells that downregulate MHC expression to avoid an MHC-restricted, T-cell immune response. Normal cells escape lysis because their MHC molecules are recognized by NK-cell inhibitory receptors, which inhibit lysis. Several such inhibitory receptor families have been described in humans and mice. In the human killer-cell inhibitory receptor family, individual p58 members are specific for a subset of class I human leukocyte antigen (HLA)-C molecules. The human p58 natural killer-cell inhibitory receptor clone 42 recognizes HLA-Cw4, -Cw2 and -Cw6, but not HLA-Cw3, -Cw2, -Cw7 or -Cw8, which are recognized by p58 killer-cell inhibitor receptor clone 43. We have determined the X-ray structure of the p58 NK-cell inhibitory receptor clone 42 at 1.7-A resolution. The structure has tandem immunoglobulin-like domains positioned at an acute, 60-degree angle. Loops on the outside of the elbow between the domains form a binding site projected away from the NK-cell surface. The topology of the domains and their arrangement relative to each other reveal a relationship to the haematopoietic receptor family, with implications for the signalling mechanism in NK cells.

PubMed: 9288975
DOI: 10.1038/38028

実験手法

X-RAY DIFFRACTION (1.7 Å)