1NIK

Wild Type RNA Polymerase II

1NIK の概要

• エントリーDOI: 10.2210/pdb1nik/pdb
• 分子名称: RPB1, DNA-directed RNA polymerase II, chain RPB10, DNA-directed RNA polymerase II, chain RPB11, ... (13 entities in total)
• 機能のキーワード: transferase, transcription
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Nucleus: P04050 P08518 P16370 P20434 P20436 P38902; Nucleus, nucleolus : P40422 P27999 P22139; Cytoplasm : P20435
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 498289.58

構造登録者

Bushnell, D.A.,Kornberg, R.D. (登録日: 2002-12-24, 公開日: 2003-04-29, 最終更新日: 2024-11-13)

主引用文献

Bushnell, D.A.,Kornberg, R.D.
Complete, 12-subunit RNA Polymerase II at 4.1-A resolution: implications for the initiation of transcription.
Proc.Natl.Acad.Sci.USA, 100:6969-6973, 2003

PubMed Abstract: The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.

PubMed: 12746498
DOI: 10.1073/pnas.1130601100

実験手法

X-RAY DIFFRACTION (4.1 Å)