1NH0

1.03 A structure of HIV-1 protease: inhibitor binding inside and outside the active site

Summary for 1NH0

Entry DOI	10.2210/pdb1nh0/pdb
Related PRD ID	PRD_000401
Descriptor	PROTEASE RETROPEPSIN, peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2, SULFATE ION, ... (5 entities in total)
Functional Keywords	aspartyl protease, human immunodeficiency virus, inhibitor design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	4
Total formula weight	23421.42
Authors	Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Hradilek, M.,Soucek, M.,Konvalinka, J.,Sedlacek, J. (deposition date: 2002-12-18, release date: 2004-04-13, Last modification date: 2023-08-16)
Primary citation	Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Stouracova, R.,Sedlacek, J.,Soucek, M.,Hradilek, M.,Lepsik, M.,Konvalinka, J. A Phenylnorstatine Inhibitor Binding to HIV-1 Protease: Geometry, Protonation, and Subsite-Pocket Interactions Analyzed at Atomic Resolution J.Med.Chem., 47:2030-2036, 2004 Cited by PubMed: 15056001 DOI: 10.1021/jm031105q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.03 Å)

Structure validation