1NH0

1.03 A structure of HIV-1 protease: inhibitor binding inside and outside the active site

1NH0 の概要

• エントリーDOI: 10.2210/pdb1nh0/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000401
• 分子名称: PROTEASE RETROPEPSIN, peptidomimetic inhibitor KI2-PHE-GLU-GLU-NH2, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: aspartyl protease, human immunodeficiency virus, inhibitor design, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 23421.42

構造登録者

Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Hradilek, M.,Soucek, M.,Konvalinka, J.,Sedlacek, J. (登録日: 2002-12-18, 公開日: 2004-04-13, 最終更新日: 2023-08-16)

• 主引用文献: Brynda, J.,Rezacova, P.,Fabry, M.,Horejsi, M.,Stouracova, R.,Sedlacek, J.,Soucek, M.,Hradilek, M.,Lepsik, M.,Konvalinka, J.; A Phenylnorstatine Inhibitor Binding to HIV-1 Protease: Geometry, Protonation, and Subsite-Pocket Interactions Analyzed at Atomic Resolution; J.Med.Chem., 47:2030-2036, 2004; PubMed: 15056001; DOI: 10.1021/jm031105q

実験手法

X-RAY DIFFRACTION (1.03 Å)