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1NFI

I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX

1NFI の概要
エントリーDOI10.2210/pdb1nfi/pdb
分子名称NF-KAPPA-B P65, NF-KAPPA-B P50, I-KAPPA-B-ALPHA, ... (4 entities in total)
機能のキーワードcomplex (transcription regulation-ank repeat), ankyrin repeat, complex (transcription reg-ank repeat) complex, complex (transcription reg/ank repeat)
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Nucleus: Q04206 P19838
Cytoplasm: P25963
タンパク質・核酸の鎖数6
化学式量合計140603.66
構造登録者
Jacobs, M.D.,Harrison, S.C. (登録日: 1998-08-25, 公開日: 1998-11-18, 最終更新日: 2024-02-14)
主引用文献Jacobs, M.D.,Harrison, S.C.
Structure of an IkappaBalpha/NF-kappaB complex.
Cell(Cambridge,Mass.), 95:749-758, 1998
Cited by
PubMed Abstract: The inhibitory protein, IkappaBalpha, sequesters the transcription factor, NF-kappaB, as an inactive complex in the cytoplasm. The structure of the IkappaBalpha ankyrin repeat domain, bound to a partially truncated NF-kappaB heterodimer (p50/ p65), has been determined by X-ray crystallography at 2.7 A resolution. It shows a stack of six IkappaBalpha ankyrin repeats facing the C-terminal domains of the NF-kappaB Rel homology regions. Contacts occur in discontinuous patches, suggesting a combinatorial quality for ankyrin repeat specificity. The first two repeats cover an alpha helically ordered segment containing the p65 nuclear localization signal. The position of the sixth ankyrin repeat shows that full-length IkappaBalpha will occlude the NF-kappaB DNA-binding cleft. The orientation of IkappaBalpha in the complex places its N- and C-terminal regions in appropriate locations for their known regulatory functions.
PubMed: 9865693
DOI: 10.1016/S0092-8674(00)81698-0
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.7 Å)
構造検証レポート
Validation report summary of 1nfi
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-23に公開中

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