1NDE

Estrogen Receptor beta with Selective Triazine Modulator

1NDE の概要

• エントリーDOI: 10.2210/pdb1nde/pdb
• 分子名称: Estrogen receptor beta, 4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL (3 entities in total)
• 機能のキーワード: estrogen receptor, estrogen receptor beta, er, erb, triazine, estrogen, estradiol, oestrogen, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q92731
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29595.60

構造登録者

Henke, B.R.,Consler, T.G.,Go, N.,Hale, R.L.,Hohman, D.R.,Jones, S.A.,Lu, A.T.,Moore, L.B.,Moore, J.T.,Orband-Miller, L.A.,Robinett, R.G.,Shearin, J.,Spearing, P.K.,Stewart, E.L.,Turnbull, P.S.,Weaver, S.L.,Williams, S.P.,Wisely, G.B.,Lambert, M.H. (登録日: 2002-12-09, 公開日: 2002-12-18, 最終更新日: 2023-08-16)

• 主引用文献: Henke, B.R.,Consler, T.G.,Go, N.,Hale, R.L.,Hohman, D.R.,Jones, S.A.,Lu, A.T.,Moore, L.B.,Moore, J.T.,Orband-Miller, L.A.,Robinett, R.G.,Shearin, J.,Spearing, P.K.,Stewart, E.L.,Turnbull, P.S.,Weaver, S.L.,Williams, S.P.,Wisely, G.B.,Lambert, M.H.; A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor beta; J.Med.Chem., 45:5492-5505, 2002; PubMed: 12459017; DOI: 10.1021/jm020291h

実験手法

X-RAY DIFFRACTION (3 Å)