1N9A

Farnesyltransferase complex with tetrahydropyridine inhibitors

Summary for 1N9A

Entry DOI	10.2210/pdb1n9a/pdb
Related	1N94 1N95
Descriptor	Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
Functional Keywords	farnesyltransferase, tetrahydropyridine, prenyltransferase, transferase
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	2
Total formula weight	83824.45
Authors	Gwaltney II, S.L.,O'Conner, S.J.,Nelson, L.T.,Sullivan, G.M.,Imade, H.,Wang, W.,Hasvold, L.,Li, Q.,Cohen, J.,Gu, W.Z. (deposition date: 2002-11-22, release date: 2003-01-07, Last modification date: 2024-02-14)
Primary citation	Gwaltney II, S.L.,O'Connor, S.J.,Nelson, L.T.,Sullivan, G.M.,Imade, H.,Wang, W.,Hasvold, L.,Li, Q.,Cohen, J.,Gu, W.Z.,Tahir, S.K.,Bauch, J.,Marsh, K.,Ng, S.C.,Frost, D.J.,Zhang, H.,Muchmore, S.,Jakob, C.G.,Stoll, V.,Hutchins, C.,Rosenberg, S.H.,Sham, H.L. Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. Bioorg.Med.Chem.Lett., 13:1363-1366, 2003 Cited by PubMed: 12657283 DOI: 10.1016/S0960-894X(03)00094-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation