1N9A

Farnesyltransferase complex with tetrahydropyridine inhibitors

1N9A の概要

• エントリーDOI: 10.2210/pdb1n9a/pdb
• 関連するPDBエントリー: 1N94 1N95
• 分子名称: Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
• 機能のキーワード: farnesyltransferase, tetrahydropyridine, prenyltransferase, transferase
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83824.45

構造登録者

Gwaltney II, S.L.,O'Conner, S.J.,Nelson, L.T.,Sullivan, G.M.,Imade, H.,Wang, W.,Hasvold, L.,Li, Q.,Cohen, J.,Gu, W.Z. (登録日: 2002-11-22, 公開日: 2003-01-07, 最終更新日: 2024-02-14)

• 主引用文献: Gwaltney II, S.L.,O'Connor, S.J.,Nelson, L.T.,Sullivan, G.M.,Imade, H.,Wang, W.,Hasvold, L.,Li, Q.,Cohen, J.,Gu, W.Z.,Tahir, S.K.,Bauch, J.,Marsh, K.,Ng, S.C.,Frost, D.J.,Zhang, H.,Muchmore, S.,Jakob, C.G.,Stoll, V.,Hutchins, C.,Rosenberg, S.H.,Sham, H.L.; Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.; Bioorg.Med.Chem.Lett., 13:1363-1366, 2003; PubMed: 12657283; DOI: 10.1016/S0960-894X(03)00094-5

実験手法

X-RAY DIFFRACTION (3.2 Å)