1N8Z
Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab
Summary for 1N8Z
| Entry DOI | 10.2210/pdb1n8z/pdb |
| Related | 1M6B 1N8Y |
| Descriptor | Herceptin Fab (antibody) - light chain, Herceptin Fab (antibody) - heavy chain, Receptor protein-tyrosine kinase erbB-2, ... (6 entities in total) |
| Functional Keywords | tyrosin kinase receptor, cell surface receptor, transferase |
| Biological source | Mus musculus, Homo sapiens (mouse/human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 114418.80 |
| Authors | Cho, H.-S.,Mason, K.,Ramyar, K.X.,Stanley, A.M.,Gabelli, S.B.,Denney Jr., D.W.,Leahy, D.J. (deposition date: 2002-11-21, release date: 2003-02-18, Last modification date: 2023-08-16) |
| Primary citation | Cho, H.-S.,Mason, K.,Ramyar, K.X.,Stanley, A.M.,Gabelli, S.B.,Denney Jr., D.W.,Leahy, D.J. Structure of the Extracellular Region of HER2 Alone and in Complex with the Herceptin Fab Nature, 421:756-760, 2003 Cited by PubMed: 12610629DOI: 10.1038/nature01392 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.52 Å) |
Structure validation
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