1N5B

Crystal Structure Of The Yersinia enterocolitica Molecular Chaperone Syce

「1MD1」から置き換えられました

1N5B の概要

• エントリーDOI: 10.2210/pdb1n5b/pdb
• 関連するPDBエントリー: 1JYA 1K6Z 1L2W 1MD1
• 分子名称: YOPE regulator (2 entities in total)
• 機能のキーワード: yersinia enterocolitica, molecular chaperone, type iii secretion system, chaperone
• 由来する生物種: Yersinia enterocolitica
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 59359.01

構造登録者

Trame, C.B.,McKay, D.B. (登録日: 2002-11-05, 公開日: 2002-11-20, 最終更新日: 2024-02-14)

主引用文献

Trame, C.B.,McKay, D.B.
Structure of the Yersinia enterocolitica molecular-chaperone protein SycE.
Acta Crystallogr.,Sect.D, 59:389-392, 2003

PubMed Abstract: The crystal structure of the Yersinia enterocolitica molecular-chaperone protein SycE, which specifically binds the YopE protein, has been solved to 2.0 A resolution by molecular replacement. The crystal contains two SycE dimers per asymmetric unit; a novel feature of this crystal, when compared with closely related SycE structures, is a well ordered carboxy-terminal peptide in one protomer of each dimer. The peptide binds a hydrophobic patch of a neighboring molecule in a manner similar to that seen in a SycE-YopE chaperone-target complex, suggestive of low-affinity 'self-binding' through which the carboxy-terminal peptide might suppress counterproductive interactions with non-target proteins in vivo.

PubMed: 12554962
DOI: 10.1107/S0907444902020826

実験手法

X-RAY DIFFRACTION (2 Å)