1N4Y

REFINED STRUCTURE OF KISTRIN

「1KST」から置き換えられました

1N4Y の概要

• エントリーDOI: 10.2210/pdb1n4y/pdb
• 関連するPDBエントリー: 1kst
• 分子名称: KISTRIN (1 entity in total)
• 機能のキーワード: beta, venom, blood coagulation, rgd, blood clotting
• 由来する生物種: Calloselasma rhodostoma (Malayan pit viper)
• 細胞内の位置: Secreted: P30403
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7341.36

構造登録者

Krezel, A.M.,Krane, J.,Dennis, M.S.,Lazarus, R.A.,Wagner, G. (登録日: 2002-11-02, 公開日: 2003-01-28, 最終更新日: 2024-11-13)

主引用文献

Adler, M.,Lazarus, R.A.,Dennis, M.S.,Wagner, G.
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
Science, 253:445-448, 1991

PubMed Abstract: The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.

PubMed: 1862345

実験手法

SOLUTION NMR