1N4X

Structure of scFv 1696 at acidic pH

1N4X の概要

• エントリーDOI: 10.2210/pdb1n4x/pdb
• 関連するPDBエントリー: 1cl7 1jp5
• 分子名称: immunoglobulin kappa chain variable region, immunoglobulin heavy chain variable region, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: immunoglobulin, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 52082.65

構造登録者

Lescar, J.,Brynda, J.,Fabry, M.,Horejsi, M.,Rezacova, P.,Sedlacek, J.,Bentley, G.A. (登録日: 2002-11-02, 公開日: 2003-06-10, 最終更新日: 2024-11-13)

主引用文献

Lescar, J.,Brynda, J.,Fabry, M.,Horejsi, M.,Rezacova, P.,Sedlacek, J.,Bentley, G.A.
Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases.
Acta Crystallogr.,Sect.D, 59:955-957, 2003

PubMed Abstract: The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of 1696 (scFv-1696) in the non-complexed form, solved at 1.7 A resolution, is compared with the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures.

PubMed: 12777823
DOI: 10.1107/S0907444903003597

実験手法

X-RAY DIFFRACTION (1.7 Å)