1N49

Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy

Summary for 1N49

• Entry DOI: 10.2210/pdb1n49/pdb
• Related: 1F7A 1HXW
• Related PRD ID: PRD_001001
• Descriptor: Protease, RITONAVIR (3 entities in total)
• Functional Keywords: hiv-1 protease, drug resistance, substrate recognition, inhibitor binding, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 4
• Total formula weight: 44532.78

Authors

Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (deposition date: 2002-10-30, release date: 2003-01-07, Last modification date: 2024-02-14)

• Primary citation: Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.; Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy; J.VIROL., 77:1306-1315, 2003; PubMed: 12502847; DOI: 10.1128/JVI.77.2.1306-1315.2003

Experimental method

X-RAY DIFFRACTION (2.2 Å)