1N49
Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy
Summary for 1N49
Entry DOI | 10.2210/pdb1n49/pdb |
Related | 1F7A 1HXW |
Related PRD ID | PRD_001001 |
Descriptor | Protease, RITONAVIR (3 entities in total) |
Functional Keywords | hiv-1 protease, drug resistance, substrate recognition, inhibitor binding, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 4 |
Total formula weight | 44532.78 |
Authors | Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (deposition date: 2002-10-30, release date: 2003-01-07, Last modification date: 2024-02-14) |
Primary citation | Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy J.VIROL., 77:1306-1315, 2003 Cited by PubMed: 12502847DOI: 10.1128/JVI.77.2.1306-1315.2003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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