1N49

Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy

1N49 の概要

• エントリーDOI: 10.2210/pdb1n49/pdb
• 関連するPDBエントリー: 1F7A 1HXW
• 関連するBIRD辞書のPRD_ID: PRD_001001
• 分子名称: Protease, RITONAVIR (3 entities in total)
• 機能のキーワード: hiv-1 protease, drug resistance, substrate recognition, inhibitor binding, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44532.78

構造登録者

Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2002-10-30, 公開日: 2003-01-07, 最終更新日: 2024-02-14)

• 主引用文献: Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.; Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy; J.VIROL., 77:1306-1315, 2003; PubMed: 12502847; DOI: 10.1128/JVI.77.2.1306-1315.2003

実験手法

X-RAY DIFFRACTION (2.2 Å)