1N49

Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy

1N49 の概要

関連するPDBエントリー1F7A 1HXW
関連するBIRD辞書のPRD_IDPRD_001001
分子名称Protease, RITONAVIR (3 entities in total)
機能のキーワードhiv-1 protease, drug resistance, substrate recognition, inhibitor binding, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Human immunodeficiency virus 1
細胞内の位置Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03369
ポリマー鎖数4
分子量合計44532.78
構造登録者
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A. (登録日: 2002-10-30, 公開日: 2003-01-07, 最終更新日: 2017-10-11)
主引用文献
Prabu-Jeyabalan, M.,Nalivaika, E.A.,King, N.M.,Schiffer, C.A.
Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant: Structural Insights for Better Antiviral Therapy
J.VIROL., 77:1306-1315, 2003
PubMed: 12502847 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.77.2.1306-1315.2003
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers291.0%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード