1N3I

Crystal Structure of Mycobacterium tuberculosis PNP with transition state analog DADMe-ImmH

1N3I の概要

• エントリーDOI: 10.2210/pdb1n3i/pdb
• 関連するPDBエントリー: 1G2O
• 分子名称: Purine Nucleoside Phosphorylase, PHOSPHATE ION, 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
• 機能のキーワード: transition state complex, trimer, pnp, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 83879.15

構造登録者

Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L. (登録日: 2002-10-28, 公開日: 2003-09-30, 最終更新日: 2023-10-25)

• 主引用文献: Lewandowicz, A.,Shi, W.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Basso, L.A.,Santos, D.S.,Almo, S.C.,Schramm, V.L.; Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase; BIOCHEMISTRY, 42:6057-6066, 2003; PubMed: 12755607; DOI: 10.1021/bi0343830

実験手法

X-RAY DIFFRACTION (1.9 Å)