1N2V

Crystal Structure of TGT in complex with 2-Butyl-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione

1N2V の概要

• エントリーDOI: 10.2210/pdb1n2v/pdb
• 関連するPDBエントリー: 1ENU 1PUD
• 分子名称: Queuine tRNA-ribosyltransferase, ZINC ION, 2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE, ... (4 entities in total)
• 機能のキーワード: protein-ligand complex, transferase
• 由来する生物種: Zymomonas mobilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43199.33

構造登録者

Brenk, R.,Naerum, L.,Graedler, U.,Gerber, H.-D.,Garcia, G.A.,Reuter, K.,Stubbs, M.T.,Klebe, G. (登録日: 2002-10-24, 公開日: 2003-04-08, 最終更新日: 2024-02-14)

• 主引用文献: Brenk, R.,Naerum, L.,Graedler, U.,Gerber, H.-D.,Garcia, G.A.,Reuter, K.,Stubbs, M.T.,Klebe, G.; Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis; J.Med.Chem., 46:1133-1143, 2003; PubMed: 12646024; DOI: 10.1021/jm0209937

実験手法

X-RAY DIFFRACTION (2.1 Å)