1MY8

AmpC beta-lactamase in complex with an M.carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain

Summary for 1MY8

• Entry DOI: 10.2210/pdb1my8/pdb
• Related: 1FSY 1KE4 1MXO
• Descriptor: beta-lactamase, PHOSPHATE ION, (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID, ... (4 entities in total)
• Functional Keywords: ampc, beta-lactamase, cephalosporinase, serine hydrolase, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79821.08

Authors

Morandi, F.,Caselli, E.,Morandi, S.,Focia, P.J.,Blazquez, J.,Shoichet, B.K.,Prati, F. (deposition date: 2002-10-03, release date: 2003-03-04, Last modification date: 2011-07-13)

• Primary citation: Morandi, F.,Caselli, E.,Morandi, S.,Focia, P.J.,Blazquez, J.,Shoichet, B.K.,Prati, F.; Nanomolar inhibitors of AmpC beta-lactamase.; J.Am.Chem.Soc., 125:685-695, 2003; PubMed: 12526668; DOI: 10.1021/ja0288338

Experimental method

X-RAY DIFFRACTION (1.72 Å)