1MW4

Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139

1MW4 の概要

• エントリーDOI: 10.2210/pdb1mw4/pdb
• 分子名称: Growth factor receptor-bound protein 7, Receptor protein-tyrosine kinase erbB-2 (2 entities in total)
• 機能のキーワード: sh2 domain in complex with a ligand, hormone-growth factor-transferase complex, hormone/growth factor/transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: Q14451; Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14956.92

構造登録者

Ivancic, M.,Lyons, B.A. (登録日: 2002-09-27, 公開日: 2003-09-09, 最終更新日: 2012-05-02)

• 主引用文献: Ivancic, M.,Daly, R.J.,Lyons, B.A.; Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2; J.BIOMOL.NMR, 27:205-219, 2003; PubMed: 12975581; DOI: 10.1023/A:1025498409113

実験手法

SOLUTION NMR