1MV0

NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC

Summary for 1MV0

Entry DOI	10.2210/pdb1mv0/pdb
Related	1MUZ 1MV3
Descriptor	Myc proto-oncogene protein, Myc box-dependent-interacting protein 1 (2 entities in total)
Functional Keywords	tumor suppressor/oncoprotein, endocytosis/exocytosis, transcription complex, endocytosis-exocytosis, transcription
Biological source	Homo sapiens (human) More
Cellular location	Nucleus, nucleoplasm: P01106 Isoform BIN1: Nucleus. Isoform IIA: Cytoplasm: O00499
Total number of polymer chains	2
Total formula weight	10836.20
Authors	Pineda-Lucena, A.,Arrowsmith, C.H. (deposition date: 2002-09-24, release date: 2003-09-30, Last modification date: 2022-02-23)
Primary citation	Pineda-Lucena, A.,Ho, C.S.,Mao, D.Y.,Sheng, Y.,Laister, R.C.,Muhandiram, R.,Lu, Y.,Seet, B.T.,Katz, S.,Szyperski, T.,Penn, L.Z.,Arrowsmith, C.H. A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. J.Mol.Biol., 351:182-194, 2005 Cited by PubMed: 15992821 DOI: 10.1016/j.jmb.2005.05.046 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation