1MUP

PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY

Summary for 1MUP

• Entry DOI: 10.2210/pdb1mup/pdb
• Descriptor: MAJOR URINARY PROTEIN, CADMIUM ION, 2-(SEC-BUTYL)THIAZOLE, ... (4 entities in total)
• Functional Keywords: pheromone-binding
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 19721.17

Authors

Bocskei, Z.,Flower, D.R.,Groom, C.R.,Phillips, S.E.V.,North, A.C.T. (deposition date: 1992-09-21, release date: 1994-01-31, Last modification date: 2024-10-23)

Primary citation

Bocskei, Z.,Groom, C.R.,Flower, D.R.,Wright, C.E.,Phillips, S.E.,Cavaggioni, A.,Findlay, J.B.,North, A.C.
Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography.
Nature, 360:186-188, 1992

PubMed Abstract: The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well characterized, although their functions remain unclear. Male rat urine affects the behaviour and sexual response of female rats, leading to the proposal that rodent urinary proteins are responsible for binding pheromones and their subsequent release from drying urine. Urinary alpha 2-globulin is also involved in hyaline droplet nephropathy, an important toxicological syndrome in male rats resulting from exposure to a number of industrial chemicals and characterized by the accumulation of liganded urinary alpha 2-globulin in lysosomes in the kidney, followed by the induction of renal cancer. We now report the three-dimensional structures of mouse major urinary protein (at 2.4 A resolution) and rat urinary alpha 2-globulin (at 2.8 A resolution). The results corroborate the role of these proteins in pheromone transport and elaborate the structural basis of ligand binding.

PubMed: 1279439
DOI: 10.1038/360186a0

Experimental method

X-RAY DIFFRACTION (2.4 Å)