1MRQ
Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone
Summary for 1MRQ
Entry DOI | 10.2210/pdb1mrq/pdb |
Descriptor | Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (5 entities in total) |
Functional Keywords | 20alpha-hsd, hydroxysteroid dehydrogenase, progesterone, ternary complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q04828 |
Total number of polymer chains | 1 |
Total formula weight | 37972.27 |
Authors | Couture, J.F.,Legrand, P.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. (deposition date: 2002-09-18, release date: 2003-09-30, Last modification date: 2024-02-14) |
Primary citation | Couture, J.F.,Legrand, P.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. J.Mol.Biol., 331:593-604, 2003 Cited by PubMed: 12899831DOI: 10.1016/S0022-2836(03)00762-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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