1MRQ

Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone

1MRQ の概要

• エントリーDOI: 10.2210/pdb1mrq/pdb
• 分子名称: Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, ... (5 entities in total)
• 機能のキーワード: 20alpha-hsd, hydroxysteroid dehydrogenase, progesterone, ternary complex, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q04828
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37972.27

構造登録者

Couture, J.F.,Legrand, P.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. (登録日: 2002-09-18, 公開日: 2003-09-30, 最終更新日: 2024-02-14)

• 主引用文献: Couture, J.F.,Legrand, P.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R.; Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.; J.Mol.Biol., 331:593-604, 2003; PubMed: 12899831; DOI: 10.1016/S0022-2836(03)00762-9

実験手法

X-RAY DIFFRACTION (1.59 Å)