1MP6

Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy

1MP6 の概要

• エントリーDOI: 10.2210/pdb1mp6/pdb
• 分子名称: Matrix protein M2 (1 entity in total)
• 機能のキーワード: influenza a virus, membrane protein structure, m2 proton channel, solid state nmr, membrane protein
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2730.30

構造登録者

Wang, J.,Kim, S.,Kovacs, F.,Cross, T.A. (登録日: 2002-09-11, 公開日: 2002-09-25, 最終更新日: 2024-05-22)

主引用文献

Wang, J.,Kim, S.,Kovacs, F.,Cross, T.A.
Structure of the transmembrane region of the M2 protein H(+) channel.
Protein Sci., 10:2241-2250, 2001

PubMed Abstract: The transmembrane domain of the M2 protein from influenza A virus forms a nearly uniform and ideal helix in a liquid crystalline bilayer environment. The exposure of the hydrophilic backbone structure is minimized through uniform hydrogen bond geometry imposed by the low dielectric lipid environment. A high-resolution structure of the monomer backbone and a detailed description of its orientation with respect to the bilayer were achieved using orientational restraints from solid-state NMR. With this unique information, the tetrameric structure of this H(+) channel is constrained substantially. Features of numerous published models are discussed in light of the experimental structure of the monomer and derived features of the tetrameric bundle.

PubMed: 11604531
DOI: 10.1110/ps.17901

実験手法

SOLID-STATE NMR