1MOE

The three-dimensional structure of an engineered scFv T84.66 dimer or diabody in VL to VH linkage.

1MOE の概要

• エントリーDOI: 10.2210/pdb1moe/pdb
• 分子名称: anti-CEA mAb T84.66, SULFATE ION (3 entities in total)
• 機能のキーワード: anti carcinoembryonic antigen, t84.66, diabody, dimer, scfv, variable domain, immune system
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51919.43

構造登録者

Carmichael, J.A.,Power, B.E.,Garrett, T.P.J.,Yazaki, P.J.,Shively, J.E.,Raubischek, A.A.,Wu, A.M.,Hudson, P.J. (登録日: 2002-09-09, 公開日: 2003-03-18, 最終更新日: 2023-10-25)

• 主引用文献: Carmichael, J.A.,Power, B.E.,Garrett, T.P.,Yazaki, P.J.,Shively, J.E.,Raubischek, A.A.,Wu, A.M.,Hudson, P.J.; The Crystal Structure of an Anti-CEA scFv Diabody Assembled from T84.66 scFvs in VL-to-VH Orientation: Implications for Diabody Flexibility; J.Mol.Biol., 326:341-351, 2003; PubMed: 12559905; DOI: 10.1016/S0022-2836(02)01428-6

実験手法

X-RAY DIFFRACTION (2.6 Å)