1MN8
Structure of Moloney Murine Leukaemia Virus Matrix Protein
Summary for 1MN8
Entry DOI | 10.2210/pdb1mn8/pdb |
Descriptor | Core protein p15 (2 entities in total) |
Functional Keywords | helical bundle, viral protein |
Biological source | Moloney murine leukemia virus |
Cellular location | Gag polyprotein: Virion (By similarity). Matrix protein p15: Virion (Potential). Capsid protein p30: Virion (Potential). Nucleocapsid protein p10: Virion (Potential): P03332 |
Total number of polymer chains | 4 |
Total formula weight | 45792.20 |
Authors | Riffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E. (deposition date: 2002-09-05, release date: 2003-01-14, Last modification date: 2024-02-14) |
Primary citation | Riffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E. Atomic resolution structure of Moloney murine leukaemia virus matrix protein and its relationship to other retroviral matrix proteins. Structure, 10:1627-1636, 2002 Cited by PubMed Abstract: Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins. PubMed: 12467570DOI: 10.1016/S0969-2126(02)00896-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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