1MN8

Structure of Moloney Murine Leukaemia Virus Matrix Protein

Summary for 1MN8

• Entry DOI: 10.2210/pdb1mn8/pdb
• Descriptor: Core protein p15 (2 entities in total)
• Functional Keywords: helical bundle, viral protein
• Biological source: Moloney murine leukemia virus
• Cellular location: Gag polyprotein: Virion (By similarity). Matrix protein p15: Virion (Potential). Capsid protein p30: Virion (Potential). Nucleocapsid protein p10: Virion (Potential): P03332
• Total number of polymer chains: 4
• Total formula weight: 45792.20

Authors

Riffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E. (deposition date: 2002-09-05, release date: 2003-01-14, Last modification date: 2024-02-14)

Primary citation

Riffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E.
Atomic resolution structure of Moloney murine leukaemia virus matrix protein and its relationship to other retroviral matrix proteins.
Structure, 10:1627-1636, 2002

PubMed Abstract: Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.

PubMed: 12467570
DOI: 10.1016/S0969-2126(02)00896-1

Experimental method

X-RAY DIFFRACTION (1 Å)