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1MN8

Structure of Moloney Murine Leukaemia Virus Matrix Protein

Summary for 1MN8
Entry DOI10.2210/pdb1mn8/pdb
DescriptorCore protein p15 (2 entities in total)
Functional Keywordshelical bundle, viral protein
Biological sourceMoloney murine leukemia virus
Cellular locationGag polyprotein: Virion (By similarity). Matrix protein p15: Virion (Potential). Capsid protein p30: Virion (Potential). Nucleocapsid protein p10: Virion (Potential): P03332
Total number of polymer chains4
Total formula weight45792.20
Authors
Riffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E. (deposition date: 2002-09-05, release date: 2003-01-14, Last modification date: 2024-02-14)
Primary citationRiffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E.
Atomic resolution structure of Moloney murine leukaemia virus matrix protein and its relationship to other retroviral matrix proteins.
Structure, 10:1627-1636, 2002
Cited by
PubMed Abstract: Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.
PubMed: 12467570
DOI: 10.1016/S0969-2126(02)00896-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1 Å)
Structure validation

238582

數據於2025-07-09公開中

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