1MN8

Structure of Moloney Murine Leukaemia Virus Matrix Protein

1MN8 の概要

• エントリーDOI: 10.2210/pdb1mn8/pdb
• 分子名称: Core protein p15 (2 entities in total)
• 機能のキーワード: helical bundle, viral protein
• 由来する生物種: Moloney murine leukemia virus
• 細胞内の位置: Gag polyprotein: Virion (By similarity). Matrix protein p15: Virion (Potential). Capsid protein p30: Virion (Potential). Nucleocapsid protein p10: Virion (Potential): P03332
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 45792.20

構造登録者

Riffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E. (登録日: 2002-09-05, 公開日: 2003-01-14, 最終更新日: 2024-02-14)

主引用文献

Riffel, N.,Harlos, K.,Iourin, O.,Rao, Z.,Kingsman, A.,Stuart, D.,Fry, E.
Atomic resolution structure of Moloney murine leukaemia virus matrix protein and its relationship to other retroviral matrix proteins.
Structure, 10:1627-1636, 2002

PubMed Abstract: Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.

PubMed: 12467570
DOI: 10.1016/S0969-2126(02)00896-1

実験手法

X-RAY DIFFRACTION (1 Å)