1MMJ

Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706

1MMJ の概要

• エントリーDOI: 10.2210/pdb1mmj/pdb
• 分子名称: elastase 1, SULFATE ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: chymotrypsin family, hydrolase
• 由来する生物種: Sus scrofa (pig)
• 細胞内の位置: Secreted: P00772
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26635.72

構造登録者

Kinoshita, T. (登録日: 2002-09-04, 公開日: 2002-12-23, 最終更新日: 2024-11-20)

主引用文献

Kinoshita, T.,Nakanishi, I.,Sato, A.,Tada, T.
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor
Bioorg.Med.Chem.Lett., 13:21-24, 2003

PubMed Abstract: The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.

PubMed: 12467609
DOI: 10.1016/S0960-894X(02)00852-1

実験手法

X-RAY DIFFRACTION (2.2 Å)