1MLX

Crystal Structure Analysis of a 2'-O-[2-(Methylthio)-ethyl]-Modified Oligodeoxynucleotide Duplex

Summary for 1MLX

• Entry DOI: 10.2210/pdb1mlx/pdb
• Descriptor: 5'-D(*GP*CP*GP*TP*AP*SMTP*AP*CP*GP*C)-3' (2 entities in total)
• Functional Keywords: dna, double helix, a-form, antisense modification, nucleic acid analogue, rna affinity, nuclease resistance, protein binding affinity, high resolution structure, hydration
• Total number of polymer chains: 2
• Total formula weight: 6270.30

Authors

Prakash, T.P.,Manoharan, M.,Kawasaki, A.M.,Fraser, A.S.,Lesnik, E.A.,Sioufi, N.,Leeds, J.M.,Teplova, M.,Egli, M. (deposition date: 2002-08-31, release date: 2002-12-04, Last modification date: 2024-02-14)

• Primary citation: Prakash, T.P.,Manoharan, M.,Kawasaki, A.M.,Fraser, A.S.,Lesnik, E.A.,Sioufi, N.,Leeds, J.M.,Teplova, M.,Egli, M.; 2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA; Biochemistry, 41:11642-11648, 2002; PubMed: 12269806; DOI: 10.1021/bi020264t

Experimental method

X-RAY DIFFRACTION (1.25 Å)