1MEM

Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor

Summary for 1MEM

Entry DOI	10.2210/pdb1mem/pdb
Related PRD ID	PRD_000234
Descriptor	Cathepsin K, N-{(1R)-3-phenyl-1-[2-(phenylsulfonyl)ethyl]propyl}-N~2~-(piperazin-1-ylcarbonyl)-L-leucinamide (3 entities in total)
Functional Keywords	osteoporosis, protease, drug design, cysteine, osteoclast, disease mutation, disulfide bond, glycoprotein, lysosome, thiol protease, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	24052.19
Authors	Mcgrath, M.E. (deposition date: 1997-01-08, release date: 1998-01-14, Last modification date: 2024-11-06)
Primary citation	McGrath, M.E.,Klaus, J.L.,Barnes, M.G.,Bromme, D. Crystal structure of human cathepsin K complexed with a potent inhibitor. Nat.Struct.Biol., 4:105-109, 1997 Cited by PubMed: 9033587 DOI: 10.1038/nsb0297-105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation