1M9Z

CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN

1M9Z の概要

• エントリーDOI: 10.2210/pdb1m9z/pdb
• 関連するPDBエントリー: 1KTZ
• 分子名称: TGF-BETA RECEPTOR TYPE II, GLYCEROL (3 entities in total)
• 機能のキーワード: three finger toxin fold, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12716.34

構造登録者

Boesen, C.C.,Radaev, S.,Motyka, S.A.,Patamawenu, A.,Sun, P.D. (登録日: 2002-07-30, 公開日: 2002-09-11, 最終更新日: 2024-10-16)

主引用文献

Boesen, C.C.,Radaev, S.,Motyka, S.A.,Patamawenu, A.,Sun, P.D.
THE 1.1A CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN
Structure, 10:913-919, 2002

PubMed Abstract: Transforming growth factor beta (TGF-beta) is involved in a wide range of biological functions including development, carcinogenesis, and immune regulation. Here we report the 1.1 A resolution crystal structure of human TGF-beta type II receptor ectodomain (TBRII). The overall structure of TBRII is similar to that of activin type II receptor ectodomain (ActRII) and bone morphogenic protein receptor type IA (BRIA). It displays a three-finger toxin fold with fingers formed by the beta strand pairs beta1-beta2, beta3-beta4, and beta5-beta6. The first finger in the TBRII is significantly longer than in ActRII and BRIA and folds tightly between the second finger and the C terminus. Surface charge distributions and hydrophobic patches predict potential TBRII binding sites.

PubMed: 12121646
DOI: 10.1016/S0969-2126(02)00780-3

実験手法

X-RAY DIFFRACTION (1.05 Å)