1M7Q
Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor
1M7Q の概要
エントリーDOI | 10.2210/pdb1m7q/pdb |
分子名称 | Mitogen-activated protein kinase 14, SULFATE ION, 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE, ... (4 entities in total) |
機能のキーワード | serine/threonine kinase, atp-binding domain, inhibitor, transferase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm : Q16539 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 42584.35 |
構造登録者 | Stelmach, J.E.,Liu, L.,Patel, S.B.,Pivnichny, J.V.,Scapin, G.,Singh, S.,Hop, C.E.C.A.,Wang, Z.,Cameron, P.M.,Nichols, E.A.,O'Keefe, S.J.,O'Neill, E.A.,Schmatz, D.M.,Schwartz, C.D.,Thompson, C.M.,Zaller, D.M.,Doherty, J.B. (登録日: 2002-07-22, 公開日: 2002-12-11, 最終更新日: 2024-02-14) |
主引用文献 | Stelmach, J.E.,Liu, L.,Patel, S.B.,Pivnichny, J.V.,Scapin, G.,Singh, S.,Hop, C.E.,Wang, Z.,Strauss, J.R.,Cameron, P.M.,Nichols, E.A.,O'Keefe, S.J.,O'Neill, E.A.,Schmatz, D.M.,Schwartz, C.D.,Thompson, C.M.,Zaller, D.M.,Doherty, J.B. Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 13:277-280, 2003 Cited by PubMed: 12482439DOI: 10.1016/S0960-894X(02)00752-7 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
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