1M6F

Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove

1M6F の概要

• エントリーDOI: 10.2210/pdb1m6f/pdb
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, 3-[C-[N'-(3-CARBAMIMIDOYL-BENZYLIDENIUM)-HYDRAZINO]-[[AMINOMETHYLIDENE]AMINIUM]-IMINOMETHYL]-BENZAMIDINIUM, ... (4 entities in total)
• 機能のキーワード: nucleic acids, minor groove binder, double helix, dna-drug complex, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7703.51

構造登録者

Nguyen, B.,Lee, M.P.H.,Hamelberg, D.,Joubert, A.,Bailly, C.,Brun, R.,Neidle, S.,Wilson, W.D. (登録日: 2002-07-16, 公開日: 2002-11-15, 最終更新日: 2024-04-03)

• 主引用文献: Nguyen, B.,Lee, M.P.H.,Hamelberg, D.,Joubert, A.,Bailly, C.,Brun, R.,Neidle, S.,Wilson, W.D.; Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove; J.Am.Chem.Soc., 124:13680-13681, 2002; PubMed: 12431090; DOI: 10.1021/ja027953c

実験手法

X-RAY DIFFRACTION (1.78 Å)