1M4H

Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3

Summary for 1M4H

Related PRD IDPRD_000289
Descriptorbeta-Secretase, Inhibitor OM00-3 (3 entities in total)
Functional Keywordsmemapsin2, base, asp2, alzheimer's disease, aspartic protease, acid protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationMembrane; Single-pass type I membrane protein P56817
Total number of polymer chains4
Total molecular weight89126.5
Authors
Hong, L.,Turner, R.T.,Koelsch, G.,Ghosh, A.K.,Tang, J. (deposition date: 2002-07-02, release date: 2002-08-28, Last modification date: 2017-04-05)
Primary citation
Hong, L.,Turner, R.T.,Koelsch, G.,Shin, D.,Ghosh, A.K.,Tang, J.
Crystal Structure of Memapsin 2 (beta-Secretase) in Complex with Inhibitor OM00-3
Biochemistry, 41:10963-10967, 2002
PubMed: 12206667 (PDB entries with the same primary citation)
DOI: 10.1021/bi026232n
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27090.4%1.6%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1m4h
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Molmil generated image of 1m4h
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Molmil generated image of 1m4h
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More Biological unit images

Molmil generated image of 1m4h
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Molmil generated image of 1m4h
rotated about x axis by 90°
Molmil generated image of 1m4h
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1m4h.pdb1.gz [70.36 KB])
Coordinate files for Biological unit (1m4h.pdb2.gz [70.41 KB])