1M2Z
Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif
Summary for 1M2Z
Entry DOI | 10.2210/pdb1m2z/pdb |
Descriptor | glucocorticoid receptor, nuclear receptor coactivator 2, octyl beta-D-glucopyranoside, ... (5 entities in total) |
Functional Keywords | glucocorticoid receptor, dexamethasone, tif2, dimer interface, hormone binding pocket, charge clamp, coactivator, hormone-hormone activator complex, hormone/hormone activator |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 66183.12 |
Authors | Bledsoe, R.B.,Montana, V.G.,Stanley, T.B.,Delves, C.J.,Apolito, C.J.,Mckee, D.D.,Consler, T.G.,Parks, D.J.,Stewart, E.L.,Willson, T.M.,Lambert, M.H.,Moore, J.T.,Pearce, K.H.,Xu, H.E. (deposition date: 2002-06-26, release date: 2003-07-15, Last modification date: 2024-04-03) |
Primary citation | Bledsoe, R.B.,Montana, V.G.,Stanley, T.B.,Delves, C.J.,Apolito, C.J.,Mckee, D.D.,Consler, T.G.,Parks, D.J.,Stewart, E.L.,Willson, T.M.,Lambert, M.H.,Moore, J.T.,Pearce, K.H.,Xu, H.E. Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition Cell(Cambridge,Mass.), 110:93-105, 2002 Cited by PubMed: 12151000DOI: 10.1016/S0092-8674(02)00817-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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