1M2Z

Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a TIF2 coactivator motif

1M2Z の概要

• エントリーDOI: 10.2210/pdb1m2z/pdb
• 分子名称: glucocorticoid receptor, nuclear receptor coactivator 2, octyl beta-D-glucopyranoside, ... (5 entities in total)
• 機能のキーワード: glucocorticoid receptor, dexamethasone, tif2, dimer interface, hormone binding pocket, charge clamp, coactivator, hormone-hormone activator complex, hormone/hormone activator
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66183.12

構造登録者

Bledsoe, R.B.,Montana, V.G.,Stanley, T.B.,Delves, C.J.,Apolito, C.J.,Mckee, D.D.,Consler, T.G.,Parks, D.J.,Stewart, E.L.,Willson, T.M.,Lambert, M.H.,Moore, J.T.,Pearce, K.H.,Xu, H.E. (登録日: 2002-06-26, 公開日: 2003-07-15, 最終更新日: 2024-04-03)

• 主引用文献: Bledsoe, R.B.,Montana, V.G.,Stanley, T.B.,Delves, C.J.,Apolito, C.J.,Mckee, D.D.,Consler, T.G.,Parks, D.J.,Stewart, E.L.,Willson, T.M.,Lambert, M.H.,Moore, J.T.,Pearce, K.H.,Xu, H.E.; Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition; Cell(Cambridge,Mass.), 110:93-105, 2002; PubMed: 12151000; DOI: 10.1016/S0092-8674(02)00817-6

実験手法

X-RAY DIFFRACTION (2.5 Å)