1LZQ

Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with an ethylenamine peptidomimetic inhibitor BOC-PHE-PSI[CH2CH2NH]-PHE-GLU-PHE-NH2

1LZQ の概要

• エントリーDOI: 10.2210/pdb1lzq/pdb
• 関連するPDBエントリー: 1FQX 1IIQ 1M0B
• 関連するBIRD辞書のPRD_ID: PRD_000383
• 分子名称: PROTEASE RETROPEPSIN, N-{(3S)-3-[(tert-butoxycarbonyl)amino]-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• 機能のキーワード: hiv, peptidomimetic, ethylenamine isostere, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22405.47

構造登録者

Skalova, T.,Hasek, J.,Dohnalek, J.,Petrokova, H.,Buchtelova, E.,Soucek, M.,Majer, P.,Uhlikova, T.,Konvalinka, J. (登録日: 2002-06-11, 公開日: 2003-04-29, 最終更新日: 2024-02-14)

• 主引用文献: Skalova, T.,Hasek, J.,Dohnalek, J.,Petrokova, H.,Buchtelova, E.,Duskova, J.,Soucek, M.,Majer, P.,Uhlikova, T.,Konvalinka, J.; An Ethylenamine Inhibitor Binds Tightly to Both Wild Type and Mutant HIV-1 Proteases. Structure and Energy Study; J.Med.Chem., 46:1636-1644, 2003; PubMed: 12699382; DOI: 10.1021/jm021079g

実験手法

X-RAY DIFFRACTION (2.2 Å)