1LY4

Analysis of quinazoline and PYRIDO[2,3D]PYRIMIDINE N9-C10 reversed bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase

1LY4 の概要

• エントリーDOI: 10.2210/pdb1ly4/pdb
• 関連するPDBエントリー: 1CD2 1D8R 1DAJ 1LY3
• 分子名称: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total)
• 機能のキーワード: pcdhfr, n9-c10 reversed bridge pyridopyrimidine antifolate, oxidoreductase
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25002.32

構造登録者

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Queener, S.F.,Gangjee, A. (登録日: 2002-06-06, 公開日: 2002-08-28, 最終更新日: 2024-02-14)

• 主引用文献: Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Queener, S.F.,Gangjee, A.; Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.; Acta Crystallogr.,Sect.D, 58:1393-1399, 2002; PubMed: 12198294; DOI: 10.1107/S0907444902010442

実験手法

X-RAY DIFFRACTION (2.1 Å)