1LY3

ANALYSIS OF QUINAZOLINE AND PYRIDOPYRIMIDINE N9-C10 REVERSED BRIDGE ANTIFOLATES IN COMPLEX WITH NADP+ AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE

Summary for 1LY3

• Entry DOI: 10.2210/pdb1ly3/pdb
• Related: 1LY4
• Descriptor: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-6-[N-(2',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]QUINAZOLINE, ... (4 entities in total)
• Functional Keywords: pcdhfr reversed bridge antifolates, oxidoreductase
• Biological source: Pneumocystis carinii
• Total number of polymer chains: 1
• Total formula weight: 25001.33

Authors

Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Queener, S.F.,Gangjee, A. (deposition date: 2002-06-06, release date: 2002-08-28, Last modification date: 2024-02-14)

• Primary citation: Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Queener, S.F.,Gangjee, A.; Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.; Acta Crystallogr.,Sect.D, 58:1393-1399, 2002; PubMed: 12198294; DOI: 10.1107/S0907444902010442

Experimental method

X-RAY DIFFRACTION (1.9 Å)