1LT6

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYLGALACTOSIDE

1LT6 の概要

• エントリーDOI: 10.2210/pdb1lt6/pdb
• 分子名称: HEAT-LABILE ENTEROTOXIN, 3-nitrophenyl alpha-D-galactopyranoside (3 entities in total)
• 機能のキーワード: enterotoxin
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 121087.88

構造登録者

Merritt, E.A.,Hol, W.G.J. (登録日: 1997-10-01, 公開日: 1997-12-03, 最終更新日: 2024-10-23)

主引用文献

Merritt, E.A.,Sarfaty, S.,Feil, I.K.,Hol, W.G.
Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.
Structure, 5:1485-1499, 1997

PubMed Abstract: Escherichia coli heat-labile enterotoxin (LT) is the causative agent of traveller's diarrhoea, and it is also responsible for the deaths of hundreds of thousands of children per year in developing countries. LT is highly homologous in sequence, structure and function to cholera toxin (CT). Both toxins attack intestinal epithelial cells via specific binding to the branched pentasaccharide of ganglioside GM1 at the cell surface. A receptor-binding antagonist which blocked this interaction would potentially constitute a prophylactic drug conferring protection both against the severe effects of cholera itself and against the milder but more common disease caused by LT.

PubMed: 9384564
DOI: 10.1016/S0969-2126(97)00298-0

実験手法

X-RAY DIFFRACTION (2.2 Å)