1LQF

Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor

Summary for 1LQF

• Entry DOI: 10.2210/pdb1lqf/pdb
• Descriptor: protein-tyrosine phosphatase, non-receptor type 1, N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE (3 entities in total)
• Functional Keywords: phosphatase, phosphonates, diabetes, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• Total number of polymer chains: 4
• Total formula weight: 141023.76

Authors

Asante-Appiah, E.,Patel, S.,Dufresne, C.,Scapin, G. (deposition date: 2002-05-10, release date: 2002-07-24, Last modification date: 2023-08-16)

• Primary citation: Asante-Appiah, E.,Patel, S.,Dufresne, C.,Roy, P.,Wang, Q.,Patel, V.,Friesen, R.W.,Ramachandran, C.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G.; The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.; Biochemistry, 41:9043-9051, 2002; PubMed: 12119018; DOI: 10.1021/bi0259554

Experimental method

X-RAY DIFFRACTION (2.5 Å)