1LQF

Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor

1LQF の概要

• エントリーDOI: 10.2210/pdb1lqf/pdb
• 分子名称: protein-tyrosine phosphatase, non-receptor type 1, N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE (3 entities in total)
• 機能のキーワード: phosphatase, phosphonates, diabetes, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 141023.76

構造登録者

Asante-Appiah, E.,Patel, S.,Dufresne, C.,Scapin, G. (登録日: 2002-05-10, 公開日: 2002-07-24, 最終更新日: 2023-08-16)

• 主引用文献: Asante-Appiah, E.,Patel, S.,Dufresne, C.,Roy, P.,Wang, Q.,Patel, V.,Friesen, R.W.,Ramachandran, C.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G.; The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.; Biochemistry, 41:9043-9051, 2002; PubMed: 12119018; DOI: 10.1021/bi0259554

実験手法

X-RAY DIFFRACTION (2.5 Å)