1LN4

CRYSTAL STRUCTURE OF E. COLI YHBY

1LN4 の概要

• エントリーDOI: 10.2210/pdb1ln4/pdb
• 分子名称: Hypothetical protein yhbY (2 entities in total)
• 機能のキーワード: putative rna-binding protein; putative translation factor, rna binding protein
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P42550
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11717.67

構造登録者

Ostheimer, G.J.,Barkan, A.,Matthews, B.W. (登録日: 2002-05-02, 公開日: 2002-05-15, 最終更新日: 2024-02-14)

主引用文献

Ostheimer, G.J.,Barkan, A.,Matthews, B.W.
Crystal structure of E. coli YhbY: a representative of a novel class of RNA binding proteins
Structure, 10:1593-1601, 2002

PubMed Abstract: E. coli YhbY belongs to a conserved family of hypothetical proteins represented in eubacteria, archaea, and plants (Pfam code UPF0044). Three maize proteins harboring UPF0044-like domains are required for chloroplast group II intron splicing, and bioinformatic data suggest a role for prokaryotic UPF0044 members in translation. The crystal structure of YhbY has been determined. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome. Modeling studies indicate that the same surface is highly basic in all members of UPF0044, suggesting a conserved RNA binding surface. Taken together, the evidence suggests that members of UPF0044 constitute a previously unrecognized class of RNA binding domain.

PubMed: 12429100
DOI: 10.1016/S0969-2126(02)00886-9

実験手法

X-RAY DIFFRACTION (1.5 Å)