1LML

LEISHMANOLYSIN

1LML の概要

• エントリーDOI: 10.2210/pdb1lml/pdb
• 分子名称: LEISHMANOLYSIN, ZINC ION (3 entities in total)
• 機能のキーワード: leishmanolysin, metalloprotease, glycoprotein
• 由来する生物種: Leishmania major
• 細胞内の位置: Cell membrane; Lipid-anchor, GPI-anchor: P08148
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51673.18

構造登録者

Schlagenhauf, E.,Etges, R.,Metcalf, P. (登録日: 1997-03-13, 公開日: 1997-09-17, 最終更新日: 2024-10-23)

主引用文献

Schlagenhauf, E.,Etges, R.,Metcalf, P.
The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63).
Structure, 6:1035-1046, 1998

PubMed Abstract: Despite their medical importance, there is little available structural information for the surface antigens of infectious protozoa. Diseases caused by the protozoan parasite Leishmania are common in many developing countries. Human infection occurs during the bite of infected sandfilies, when Leishmania promastigote cells from the insect gut enter the bloodstream. Promastigotes in the blood parasitize macrophages, often causing serious disease. Leishmanolysin is the predominant protein surface antigen of promastigotes, and is assumed to have a key role during infection. Leishmanolysin is a membrane-bound zinc proteinase, active in situ. Similar molecules exist in other trypanomastid protozoa.

PubMed: 9739094
DOI: 10.1016/S0969-2126(98)00104-X

実験手法

X-RAY DIFFRACTION (1.86 Å)