1LJT

Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)

1LJT の概要

• エントリーDOI: 10.2210/pdb1ljt/pdb
• 分子名称: Macrophage migration inhibitory factor, 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER (3 entities in total)
• 機能のキーワード: protein-inhibitor complex, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P14174
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 37770.88

構造登録者

Lubetsky, J.B.,Dios, A.,Han, J.,Aljabari, B.,Ruzsicska, B.,Mitchell, R.,Lolis, E.,Al-Abed, Y. (登録日: 2002-04-22, 公開日: 2002-11-27, 最終更新日: 2024-02-14)

• 主引用文献: Lubetsky, J.B.,Dios, A.,Han, J.,Aljabari, B.,Ruzsicska, B.,Mitchell, R.,Lolis, E.,Al-Abed, Y.; The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents; J.Biol.Chem., 277:24976-24982, 2002; PubMed: 11997397; DOI: 10.1074/jbc.M203220200

実験手法

X-RAY DIFFRACTION (2 Å)