1LHF
HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BORO-HOMOLYS-OH
Summary for 1LHF
Entry DOI | 10.2210/pdb1lhf/pdb |
Descriptor | ALPHA-THROMBIN, HIRUDIN, AC-(D)PHE-PRO-BOROHOMOLYS-OH, ... (5 entities in total) |
Functional Keywords | blood coagulation, plasma, calcium-binding, glycoprotein, duplication, vitamin k, zymogen, gamma-carboxyglutamic acid, acute phase, liver, hydrolase, serine protease, kringle, disease mutation, complex (serine protease-inhibitor), complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor) |
Biological source | Hirudo medicinalis (medicinal leech) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35791.62 |
Authors | Weber, P.C.,Lee, S.L.,Lewandowski, F.A.,Schadt, M.C.,Chang, C.H.,Kettner, C.A. (deposition date: 1994-12-27, release date: 1996-11-08, Last modification date: 2024-06-05) |
Primary citation | Weber, P.C.,Lee, S.L.,Lewandowski, F.A.,Schadt, M.C.,Chang, C.W.,Kettner, C.A. Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs. Biochemistry, 34:3750-3757, 1995 Cited by PubMed: 7893672DOI: 10.1021/bi00011a033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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