1LFA

CD11A I-DOMAIN WITH BOUND MN++

1LFA の概要

• エントリーDOI: 10.2210/pdb1lfa/pdb
• 分子名称: CD11A, MANGANESE (II) ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: cell adhesion
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P20701
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42827.77

構造登録者

Leahy, D.J.,Qu, A. (登録日: 1995-09-08, 公開日: 1996-01-29, 最終更新日: 2024-02-14)

主引用文献

Qu, A.,Leahy, D.J.
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Proc.Natl.Acad.Sci.USA, 92:10277-10281, 1995

PubMed Abstract: We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may serve as a ligand-binding surface and is likely to rearrange in the absence of bound metal ion. The CD11a I-domain is homologous to domains found in von Willebrand factor, and mapping of mutations found in types 2a and 2b von Willebrand disease onto this structure allows consideration of the molecular basis of these forms of the disease.

PubMed: 7479767
DOI: 10.1073/pnas.92.22.10277

実験手法

X-RAY DIFFRACTION (1.8 Å)